Rapid and transient up-regulation of Na+/myo-inositol cotransporter transcription in the brain of acute hypernatremic rats.
作者： Yuki Minami , Kiyoshi Inoue , Shoichi Shimada , Hiroyuki Morimura , Akiko Miyai
DOI: 10.1016/0169-328X(96)00034-4
关键词:
摘要: The osmoregulatory system is well developed in the brain. Osmolytes contribute to maintenance of cell volume and cellular functions without changing intracellular ionic composition. Myo-inositol regarded as one major osmolytes In present study, we investigated changes expressions sodium myo-inositol cotransporter (SMIT) mRNA brain acute hypernatremic rats by in-situ hybridization Northern blot methods. Under moderate conditions, SMIT level increased markedly at 1 h returned almost control levels 3 h, accordance with plasma Na+ concentrations. Especially, distinct increases expression were observed granule cells glial cerebellum. These findings indicate that plays an important role osmoregulation, especially early stages hypernatremia
elsevier.com
sci-hub.se 参考文章(22)
P. R. Cammarata, Hai-Qing Chen, Osmoregulatory alterations in myo-inositol uptake by bovine lens epithelial cells. Part 1: A hypertonicity-induced protein enhances myo-inositol transport. Investigative Ophthalmology & Visual Science. ,vol. 35, pp. 1223- 1235 ,(1994)
Bhargavan Chakrapani, T. Yokoyama, Li-Ren Lin, V. N. Reddy, Hypertonic stress increases NaK ATPase, taurine, and myoinositol in human lens and retinal pigment epithelial cultures. Investigative Ophthalmology & Visual Science. ,vol. 34, pp. 2512- 2517 ,(1993)
P. R. Cammarata, Neeraj Agarwal, Cheng Zhou, Osmoregulatory alterations in myo-inositol uptake by bovine lens epithelial cells. Part 2: Cloning of a 626 bp cDNA portion of a Na+/myo-inositol cotransporter, an osmotic shock protein. Investigative Ophthalmology & Visual Science. ,vol. 35, pp. 1236- 1242 ,(1994)
H.M. Kwon, A Yamauchi, S Uchida, A.S. Preston, A Garcia-Perez, M.B. Burg, J.S. Handler, Cloning of the cDNa for a Na+/myo-inositol cotransporter, a hypertonicity stress protein. Journal of Biological Chemistry. ,vol. 267, pp. 6297- 6301 ,(1992) , 10.1016/S0021-9258(18)42695-6
Y H Lien, J I Shapiro, L Chan, Effects of hypernatremia on organic brain osmoles. Journal of Clinical Investigation. ,vol. 85, pp. 1427- 1435 ,(1990) , 10.1172/JCI114587
James W. Lohr, James McReynolds, Thomas Grimaldi, Margaret Acara, Effect of acute and chronic hypernatremia on myoinositol and sorbitol concentration in rat brain and kidney. Life Sciences. ,vol. 43, pp. 271- 276 ,(1988) , 10.1016/0024-3205(88)90317-7
Allen I. Arieff, Raul Guisado, Effects on the central nervous system of hypernatremic and hyponatremic states Kidney International. ,vol. 10, pp. 104- 116 ,(1976) , 10.1038/KI.1976.82
A Yamauchi, A Miyai, S Shimada, Y Minami, M Tohyama, E Imai, T Kamada, N Ueda, Localization and rapid regulation of Na+/myo-inositol cotransporter in rat kidney. Journal of Clinical Investigation. ,vol. 96, pp. 1195- 1201 ,(1995) , 10.1172/JCI118151
Pak H. Chan, Robert A. Fishman, Elevation of rat brain amino acids, ammonia and idiogenic osmoles induced by hyperosmolality. Brain Research. ,vol. 161, pp. 293- 301 ,(1979) , 10.1016/0006-8993(79)90070-2
T. Nakanishi, R. J. Turner, M. B. Burg, Osmoregulatory changes in myo-inositol transport by renal cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 86, pp. 6002- 6006 ,(1989) , 10.1073/PNAS.86.15.6002