Neurochemical Aspects of Thermoregulation

摘要: A quarter of a century has now elapsed since the announcement “monoamine theory” thermoregulation. From an historical perspective, concept put forward was that monoamines within hypothalamus acted essentially in balanced but functional opposition to one another bring about precise control one’s body temperature (Tb) (Feldberg and Myers 1963). Based initially on experiments utilizing intracerebroventricular (ICV) injection cat, serotonin (5-HT) found cause rise core accompanied by appropriate physiological responses for homeostatic thermogenesis including shivering vasoconstriction. Conversely, norepinephrine (NE) or epinephrine (E) injected similarly not only attenuated 5-HT-induced hyperthermia also could lower normal resting cat 1964). Later, these effects were localized anatomically micro-injection amines anterior hypothalamic, preoptic area (POAH) 1965), which is known be involved central