In vivo potential hypoglycemic and in vitro vasorelaxant effects of Cecropia glaziovii standardized extracts

摘要: The aim of this study is to investigate the effect Cecropia glaziovii Snethl, Urticaceae, extracts on oral glucose tolerance curve, glycemia in alloxan-induced diabetic rats and vasorelaxant after extraction process, standardize extractive solutions. effects process variables their interactions were calculated relation dry residue, pH, total phenolic results chemical marker content. Furthermore, (400 mg/kg), chlorogenic (2 or 15 mg/kg) caffeic acids investigated curve rats. Oral administration ethanol 4d20 8d20 significantly improved hyperglycemic Chlorogenic acids, as well association compounds able reduce gavage treatments. On other hand, aqueous did not alter glycemia. (8020 9030) only higher dose acid presented a significant serum lowering Additionally, IC50 reveals that more potent vasodilator than aortic rings. This shows C. glazioviistandardized exhibits antihyperglycemic action, improve has vascular relaxing effect. These are probably linked concentrations main extracts.