Regulation of S-Adenosylmethionine Synthesis in Human Lymphocytes
作者： Nicholas M. Kredich , Malak Kotb , Deborah Campano German , Craig A. Bloch
DOI: 10.1007/978-1-4612-5012-8_17
关键词:
摘要: The biochemistry of S-adenosylmethionine (AdoMet) provides several possible strategies for drug design. One focuses on the ability S-adenosylhomocysteine (AdoHcy) and its analogues to inhibit transmethylation reactions; involves design agents that transmethylases directly, or AdoHcy hydrolase causing accumulation, react intracellularly with homocysteine form inhibitory AdoHcy.
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