Antioxidant potential of C-phycocyanin isolated from cyanobacterial species Lyngbya, Phormidium and Spirulina spp.

摘要: The antioxidant activity of C-Phycocyanin (C-PC) isolated from three cyanobacterial species Lyngbya (marine), Phormidium (marine) and Spirulina (fresh water) was studied in vitro. results demonstrate that C-PCs Lyngbya, spp. are able to scavenge peroxyl radicals (determined by crocin bleaching assay) with relative rate constant ratio 3.13, 1.89 1.8, respectively. also hydroxyl deoxyribose degradation second order values 7.87 x 10(10), 9.58 10(10) 6.42 Interestingly, C-PC is found be an effective inhibitor (IC50 6.63 microM), as compared 12.15 microM) 12.74 close uric acid 2.15 microM). Further, the studies suggest covalently-linked tetrapyrrole chromophore phycocyanobilin involved radical scavenging C-PC. electron spin resonance (ESR) spectra indicate presence free active sites, which may play important role its property. This first report on ESR native without perturbations can cause formation.