A Genetic Variant of the Serine Racemase Gene Is Associated with Schizophrenia
作者： Yukitaka Morita , Hiroshi Ujike , Yuji Tanaka , Kyohei Otani , Makiko Kishimoto
DOI: 10.1016/J.BIOPSYCH.2006.07.025
关键词:
摘要: Background Serine racemase (SRR) is a brain-enriched enzyme that converts l -serine to d -serine, which acts as an endogenous ligand of N-methyl -aspartate (NMDA) receptors. Dysfunction SRR may reduce the function NMDA receptors and susceptibility schizophrenia. Methods We genotyped three single-nucleotide polymorphisms (SNPs) 5′ region gene in 525 patients with schizophrenia 524 healthy controls. Effects SNPs on promoter activity serum levels total were examined. Results found significant excess IVS1a+465C allele schizophrenia, especially paranoid subtype (p = .0028). A reporter assay showed had 60% lower than did IVS1a+465G allele. Conclusions The gene, reduces expression risk factor for subtype.
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