Titanium and steel fracture fixation plates with different surface topographies: Influence on infection rate in a rabbit fracture model.

摘要: Introduction Implant-related infection is a challenging complication in musculoskeletal trauma surgery. In the present study, we examined role of implant material and surface topography as influencing factors on development an experimental model plating osteosynthesis rabbit. Methods The implants included this study were composed of: standard Electropolished Stainless Steel (EPSS), titanium (Ti-S), roughened stainless steel (RSS) polished (Ti-P). Construct stability load-to-failure Ti-P was compared to that Ti-S rabbit cadaveric model. vivo humeral fracture used. Each received one three Staphylococcus aureus inocula, aimed at determining rate low, medium high dose bacteria. Outcome measures quantification bacteria surrounding tissues, determination infectious 50 (ID50). Results No significant differences observed between regarding stiffness or failure load cadaver study. Of 72 rabbits eventually developed infection. The ID50 found be: EPSS 3.89 × 103 colony forming units (CFU); RSS 8.23 × 103 CFU; 5.66 × 103 3.41 × 103 CFU. Significantly lower bacterial counts samples with (p < 0.001) inoculum. Similarly, bone animals group comparison both groups, again inoculation (p < 0.005). Conclusion No seen susceptibility when comparing conventional modified topographies. implants, which have previously been shown preclinical studies reduce complications associated tissue adherence, do not affect Therefore, are expected rate, influence clinical situation.