Insulin-Like Growth Factor-I Messenger Ribonucleic Acid in the Developing Human Placenta and in Term Placenta of Diabetics
作者： Chun-Yeh Wang , Makoto Daimon , Shu-Jane Shen , Gary L. Engelmann , Judith llan
DOI: 10.1210/MEND-2-3-217
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摘要: Fetal growth and development are dependent upon the of placenta. Control placental is little understood. Immunoreactive insulin-like factor-l -II (IGF-I IGF-II) have been shown to be released by human tissue membranes observed contain specific receptors for these factors. Furthermore, we demonstrated presence IGF-II mRNA transcripts in developing placenta at gestational term placentae diabetics. Thus, IGFs may a regulatory role via autocrine and/or paracrine mechanism(s) action. In this report demonstrate four differing size species poly(A)+ RNA which specifically hybridize an IGF-I probe originally isolated from adult liver cDNA library localize syncytiotrophoblasts fibroblasts, respectively, situ hybri...
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