An oral colon-targeting controlled release system based on resistant starch acetate: synthetization, characterization, and preparation of film-coating pellets.
作者： Huayin Pu , Ling Chen , Xiaoxi Li , Fengwei Xie , Long Yu
DOI: 10.1021/JF2005468
关键词:
摘要: An oral colon-targeting controlled release system based on resistant starch acetate (RSA) as a film-coating material was developed. The RSA was successfully synthesized, and its digestion resistibility could be improved by increasing the degree of substitution (DS), which was favorable for the colon-targeting purpose. As a delivery carrier material, the characteristics of RSA were investigated by polarized light microscopy, FTIR spectroscopy, and X-ray diffraction. The results revealed a decrease of the crystallinity of RSA and a …
acs.org
uq.edu.au
core.ac.uk参考文章(43)
Marcos R Guilherme, Adriano V Reis, Alexandre T Paulino, Thais A Moia, Luiz HC Mattoso, Elias B Tambourgi, None, Pectin‐based polymer hydrogel as a carrier for release of agricultural nutrients and removal of heavy metals from wastewater Journal of Applied Polymer Science. ,vol. 117, pp. 3146- 3154 ,(2010) , 10.1002/APP.32123
Lars Hovgaard, Helle Brondsted, Current applications of polysaccharides in colon targeting. Critical Reviews in Therapeutic Drug Carrier Systems. ,vol. 13, pp. 185- 223 ,(1996) , 10.1615/CRITREVTHERDRUGCARRIERSYST.V13.I3-4.10
A. Cristina Freire, Christiane C. Fertig, Fridrun Podczeck, Francisco Veiga, João Sousa, Starch-based coatings for colon-specific drug delivery. Part I: the influence of heat treatment on the physico-chemical properties of high amylose maize starches. European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 72, pp. 574- 586 ,(2009) , 10.1016/J.EJPB.2009.02.008
Aleksandra Dukić-Ott, Jean Paul Remon, Paul Foreman, Chris Vervaet, Immediate release of poorly soluble drugs from starch-based pellets prepared via extrusion/spheronisation. European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 67, pp. 715- 724 ,(2007) , 10.1016/J.EJPB.2007.04.014
Jaspreet Singh, Anne Dartois, Lovedeep Kaur, Starch digestibility in food matrix: a review Trends in Food Science and Technology. ,vol. 21, pp. 168- 180 ,(2010) , 10.1016/J.TIFS.2009.12.001
Yue Xu, Wanqiang Ding, Ji Liu, Ya Li, John F. Kennedy, Qun Gu, Shuangxi Shao, Preparation and characterization of organic-soluble acetylated starch nanocrystals Carbohydrate Polymers. ,vol. 80, pp. 1078- 1084 ,(2010) , 10.1016/J.CARBPOL.2010.01.027
Hui Chi, Kun Xu, Xiuli Wu, Qiang Chen, Donghua Xue, Chunlei Song, Wende Zhang, Pixin Wang, Effect of acetylation on the properties of corn starch Food Chemistry. ,vol. 106, pp. 923- 928 ,(2008) , 10.1016/J.FOODCHEM.2007.07.002
Ling Chen, Xiaoxi Li, Lin Li, Siyuan Guo, Acetylated starch-based biodegradable materials with potential biomedical applications as drug delivery systems Current Applied Physics. ,vol. 7, ,(2007) , 10.1016/J.CAP.2006.11.023
Gautam Sen, Sumit Mishra, Usha Jha, Sagar Pal, Microwave initiated synthesis of polyacrylamide grafted guar gum (GG-g-PAM)-Characterizations and application as matrix for controlled release of 5-amino salicylic acid. International Journal of Biological Macromolecules. ,vol. 47, pp. 164- 170 ,(2010) , 10.1016/J.IJBIOMAC.2010.05.004
Y Huang, A method using biodegradable polylactides/polyethylene glycol for drug release with reduced initial burst. International Journal of Pharmaceutics. ,vol. 182, pp. 93- 100 ,(1999) , 10.1016/S0378-5173(99)00060-5