History of Gestational Diabetes Mellitus in Relation to Cardiovascular Disease and Cardiovascular Risk Factors in US Women.

摘要: Background: Findings from previous studies examining the association between gestational diabetes mellitus (GDM) and subsequent risk of cardiovascular disease (CVD) have been inconsistent inconclusive. We aimed to examine associations a history GDM with CVD status factors in nationwide population-based study United States. Methods: This included 8,127 parous women aged 20 years older 2007-2014 cycles National Health Nutrition Examination Survey The exposure was self-reported diagnostic outcomes were measurements factors, including blood pressure lipids. Regression models sample weights used factors. Results: prevalence higher among than those without GDM. Among both CVD, diagnosed on average 22.9 after diagnosis After adjustment for demographic, socioeconomic, lifestyle associated 63% odds (odds ratio 1.63, 95% confidence interval (CI) 1.02, 2.62, p-value=0.04). Further body mass index (BMI) modestly attenuated 1.52, CI 0.95, 2.44, p-value=0.08). A significantly lower serum level HDL-cholesterol (adjusted β-coefficient -3.33, -5.17, -1.50, p-value≤0.001), but not total cholesterol, LDL-cholesterol, triglycerides, or systolic diastolic pressure. Similarly, HDL- cholesterol BMI -1.68, -3.38, 0.03, p-value=0.54). Conclusions: Women developing HDL-cholesterol, compared may be explained, at least partly, by BMI.