Metformin: The hidden chronicles of a magic drug
作者： Khalid Mahmood , Muhammad Naeem , Nasir Ali Rahimnajjad
DOI: 10.1016/J.EJIM.2012.10.011
关键词:
摘要: Metformin, a biguanide is well known treatment for type 2 diabetes mellitus that has diverse mechanism of actions. Various studies have elucidated the role this drug in different pathologies. The well-known United Kingdom Prospective Diabetic Study (UKPDS) observed its survival benefits large cohort individuals. Data been conclusive metformin also beneficial lipid disorders as it improves markers metabolic syndrome. Studies shown roles antipsychotic induced weight gain HIV lipodystrophy Evidence accumulating fertility females with Polycystic Ovarian Syndrome (PCOS). It delays aging and effective related equally inflammation at least rodent studies. Metformin's major effect various cancers ranging from solid to hematological malignancies. Researchers are working reveal more magic but remains an unexplored territory medical community.
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Harpal S. Randeva, Bee K. Tan, P. Hodges, Martin O. Weickert, Neuroendocrine and endocrine dysfunction in the hyperinsulinemic PCOS patient: the role of metformin. Minerva Endocrinologica. ,vol. 37, pp. 25- 40 ,(2012)
Arie Gruzman, Gali Babai, Shlomo Sasson, Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations The review of diabetic studies : RDS. ,vol. 6, pp. 13- 36 ,(2009) , 10.1900/RDS.2009.6.13
Alireza Faridar, Sonia Chowdhury, Cathrine J. DeMars, Abhayjit Singh, Gwen A. Lomberk, Ganapathy A. Prasad, Paul J. Limburg, Amitabh Chak, Navtej Buttar, Chemopreventive Potential of Metformin in Barrett's Esophagus Gastroenterology. ,vol. 140, pp. S- 220 ,(2011) , 10.1016/S0016-5085(11)60892-5
Norberto C Chavez-Tapia, Tonatiuh Barrientos-Gutierrez, Felix I Tellez-Ávila, Francisco Sánchez-Ávila, Maria Antonieta Montaño-Reyes, Misael Uribe, Insulin sensitizers in treatment of nonalcoholic fatty liver disease: Systematic review World Journal of Gastroenterology. ,vol. 12, pp. 7826- 7831 ,(2006) , 10.3748/WJG.V12.I48.7826
, 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. The Lancet. ,vol. 374, pp. 1677- 1686 ,(2009) , 10.1016/S0140-6736(09)61457-4
Kotaro Higashi, Yoshimichi Ueda, Aya Sakurai, Xiao MingWang, Linfeng Xu, Manabu Murakami, Hiroyasu Seki, Manabu Oguchi, Suzuka Taki, Yoshihiro Nambu, Hisao Tonami, Shogo Katsuda, Itaru Yamamoto, Correlation of Glut-1 glucose transporter expression with [ 18 F]FDG uptake in non-small cell lung cancer European Journal of Nuclear Medicine and Molecular Imaging. ,vol. 27, pp. 1778- 1785 ,(2000) , 10.1007/S002590000367
H Glantschnig, J E Fisher, G Wesolowski, G A Rodan, A A Reszka, M-CSF, TNFα and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase Cell Death & Differentiation. ,vol. 10, pp. 1165- 1177 ,(2003) , 10.1038/SJ.CDD.4401285
Simon D French, Melainie Cameron, Bruce F Walker, John W Reggars, Adrian J Esterman, Superficial heat or cold for low back pain Cochrane Database of Systematic Reviews. ,vol. 1, pp. 1- 42 ,(2006) , 10.1002/14651858.CD004750.PUB2
Leigh A. Cantrell, Chunxiao Zhou, Alberto Mendivil, Kimberly M. Malloy, Paola A. Gehrig, Victoria L. Bae-Jump, Metformin is a potent inhibitor of endometrial cancer cell proliferation—implications for a novel treatment strategy Gynecologic Oncology. ,vol. 116, pp. 92- 98 ,(2010) , 10.1016/J.YGYNO.2009.09.024
Barbara B. Kahn, Thierry Alquier, David Carling, D. Grahame Hardie, AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism Cell Metabolism. ,vol. 1, pp. 15- 25 ,(2005) , 10.1016/J.CMET.2004.12.003