Altered hypothalamic function in diet-induced obesity.

摘要: Energy homeostasis involves a complex network of hypothalamic and extra-hypothalamic neurons that transduce hormonal, nutrient neuronal signals into responses ultimately match caloric intake to energy expenditure thereby promote stability body fat stores. Growing evidence suggests rather than reflecting failure regulate intake, common forms obesity involve fundamental changes this homeostatic system favor the defense an elevated level adiposity. This article reviews emerging during high-fat feeding, pathogenesis alteration systems food expenditure.