THE REGULATION OF GROWTH FACTOR RECEPTORS EGFR AND IGF-IR AND THE GROWTH FACTOR VEGF BY THIOREDOXIN-1

摘要: Thioredoxin-1 (Trx-1) is a redox protein that overexpressed in many tumors where it associated with tumor growth, inhibited apoptosis and decreased patient survival. Through reactions, Trx-1 able to reduce number of proteins including transcription factors. Sp1 activation has been implicated the regulation genes involved cellular growth survival its overexpression certain cancer correlates We demonstrate activate dependent manner. increases transactivation DNA binding whereas inactive no effect on binding. vascular endothelial factor we have shown expression results increased hypoxic VEGF permeability vivo. an increase upon Sp1, as inhibition siRNA prevented induction by Trx-1. These suggest under normoxic conditions through factor. could angiogenesis relatively perfused areas contributing stimulation hypothesized may be part mechanism growth. regulates epidermal receptor (EGFR) insulin-like I (IGF-IR). two receptors are important for therapeutic targets treatment. report