Blockade of transgenic gamma delta T cell development in beta 2-microglobulin deficient mice.

摘要: The gamma delta T cell receptor (TCR) of the hybridoma KN6 recognizes self molecule encoded by a class I gene which maps within TL region major histocompatibility complex (MHC) H-2b mice. Mice transgenic (Tg) for this TCR were crossed with mice genetically deficient in beta 2-microglobulin (beta 2m). No mature Tg cells detected thymus or spleen 2m- We conclude that interaction between and 2m-associated (probably an MHC molecule) is required generation cells.