Vitexin, orientin and other flavonoids from Spirodela polyrhiza inhibit adipogenesis in 3T3-L1 cells.
作者： JinPyo Kim , IkSoo Lee , JeongJu Seo , MunYhung Jung , YoungHee Kim
DOI: 10.1002/PTR.3186
关键词:
摘要: To investigate the adipogenesis inhibitory effect on lipid accumulation, 3T3-L1 cells were treated with fractions and isolated flavonoids of Spirodela polyrhiza. An ethanol extract S. polyrhiza was fractionated into three fractions. The butanol soluble fraction (SPB) exhibited potent antiadipogenesis activity decreased C/EBPα PPARγ protein expression level in without significant cytotoxicity. from SPB their chemical structures identified as chrysoeriol (1), apigenin (2), luteolin (3), vitexin (4), cosmosin (5), orientin (6) luteolin-7-O-β-d-glucoside (7) by spectroscopic analysis. Studies intracellular triglyceride accumulation showed that compounds 4 6 had highest cells. These results suggest SPB, especially 6, contribute to
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