A COMPARATIVE STUDY OF HYDRASTINE, BICUCULLINE AND ADLUMINE

摘要: 1. The convulsant, cardiac depressant, depressor, uterine and intestinal stimulant actions of hydrastine are confirmed the ready detoxification drug is demonstrated. 2. Hydrastine bicuculline shown to be qualitatively quantitatively similar, with exception that approximately 100 times as powerful a convulsant hydrastine. convulsions produced by largely spinal origin; rapid difference in disposition various groups about asymmetric carbon atoms (as evidenced optical activity) probable explanation for central nervous system toxicity. 3. Adlumine much less regards action; slightly different type; clonic tremor legs produced; depressant action on frog heart antagonized atropine its augmentor effects tonus movements five ten great those or bicuculline. modification from hydrastine-type must due effect replacing methylenedioxy group 6:7 position isoquinoline ring dimethoxy grouping.