P.1.008 Stress rapidly reorganizes the glutamate synapse in the prefrontal cortex of cocaine-withdrawn adolescent rats

摘要: In the D3 receptor, buspirone showed a pose similar to that of SB27711A, confirming experimental data about its antagonist activity at receptor. Docking 5-HT1A no favorable binding SB277011A and alternative poses for buspirone. Conclusions: RACK1/BDNF/D3R pathway seems operate as reinforcing mechanism in voluntary ethanol intake. The pharmacological effects D3R antagonism, decreasing alcohol intake C57BL/6J WT mice, indicate receptor promising therapeutic target weaning. Moreover optimized structure models drug-targets useful understanding atomistic molecular level drugs investigated may represent important tools drug discovery agents addiction.