Mode of inheritance of hypertrophic cardiomyopathy in Iceland. Echocardiographic study.

摘要: We used an abnormally thick interventricular septum (greater than or equal to 1.3 cm) as echocardiographic marker find the inheritance pattern of hypertrophic cardiomyopathy among relatives eight patients who had that disease at necropsy. Forty normal subjects served a control group. Fifty-eight family members were examined and 18 (41%) 44 first degree cardiomyopathy. The overall was consistent with autosomal dominant genetic disorder in one recessive trait could be excluded. diagnosis can difficult clinically only 13% our serious symptoms 30% abnormal auscultatory findings. electrocardiogram is useful screening test it 20 (87%) those septum. Symmetric septal hypertrophy found this study 17% clinical evidence obstruction.