Virus crystallography and structural virology: a personal perspective

摘要: My first experiences with crystallography were as a graduate student at the University of Glasgow determining structure aromatic hydrocarbons using only primitive hand calculation techniques. I had my experience electronic computers post-doc in lab William Lipscomb Minnesota. That gave me good preparation for determination haemoglobin Max Perutz Cambridge. The discovery conserved globin fold major impact on subsequent activities. It also provided foundation development molecular replacement method and non-crystallographic symmetry electron density averaging that was essential simple icosahedral viruses. common cold virus stimulus study more complex viruses use cryo-electron microscopy. This basis investigation lipid-enveloped such Sindbis deng...