Laminin and fibronectin guideposts signal sustained but opposite effects to passing growth cones

摘要: Guidepost cells are known to alter the behavior of growth cones in vivo, yet nature communication and type signals employed largely undefined. The present study demonstrates that model guideposts, composed a single molecular species, sufficient change navigation advancing well beyond time contact. Laminin on guideposts caused sustained increase cone velocity, whereas fibronectin led decrease. A spatially discrete array multiple laminin-model maintained increased rates fibronectin, as expected for homogeneous laminin, also provided unambiguous directional guidance information. Laminin-evoked responses required activation protein kinase C-dependent intracellular signalling mechanisms.