Recent advances in developing synthetic carbohydrate-based vaccines for cancer immunotherapies

摘要: Cancer cells can often be distinguished from healthy by the expression of unique carbohydrate sequences decorating cell surface as a result aberrant glycosyltransferase activity occurring within cell; these unusual carbohydrates used valuable immunological targets in modern vaccine designs to raise carbohydrate-specific antibodies. Many tumor antigens (e.g., GM2, Ley, globo H, sialyl Tn and TF) have been identified date variety cancers. Unfortunately, alone evoke poor immunogenicity, owing their lack ability inducing T-cell-dependent immune responses. In order enhance immunogenicity promote long-lasting responses, are chemically modified link an immunogenic protein or peptide fragment for eliciting This review will present summary efforts advancements made on creating carbohydrate-based anticancer vaccines, include novel approaches overcoming t...