Effect of compounds modulating amino acid neurotransmission on the development and control of bicuculline-induced epileptogenic spiking in the rat.
作者： F. Zia-Gharib , R.A. Webster
DOI: 10.1016/0028-3908(91)90113-P
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摘要: Abstract Dose-related EEG spiking was induced and monitored in urethane-anaesthetised rats by cortical superfusion of bicuculline methiodide, through a cup incorporating recording electrodes. The total integrated spike voltage, number spikes as well the average size were monitored. Extracellular showed that each individual coincided with sudden, synchronous firing group superficial cells (layer II–III). γ-Aminobutyric acid reduced both frequency spikes, whilst muscimol clonazepam mainly spikes. (±) Baclofen no effect on their size. NMDA receptor antagonists, AP5 AP7 attenuating size, frequency. channel blocker MK801 also but increased at large concentrations; increasing magnesium artificial CSF, from 1 to 10 mM, had similar effect. Compounds believed preferentially block non-NMDA receptors, GAMS CNQX, activity reducing It is concluded activation GABAB receptors are important for controlling initiation bicuculline-induced GABAA control subsequent development.
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sci-hub.se 参考文章(42)
M. Avoli, A. Olivier, Bursting in human epileptogenic neocortex is depressed by an N-methyl-D-aspartate antagonist. Neuroscience Letters. ,vol. 76, pp. 249- 254 ,(1987) , 10.1016/0304-3940(87)90724-5
G.F. Ayala, M. Dichter, R.J. Gumnit, H. Matsumoto, W.A. Spencer, Genesis of epileptic interictal spikes. New knowledge of cortical feedback systems suggests a neurophysiological explanation of brief paroxysms Brain Research. ,vol. 52, pp. 1- 17 ,(1973) , 10.1016/0006-8993(73)90647-1
J Bancaud, J Talairach, P Morel, M Bresson, A Bonis, S Geier, E Hemon, P Buser, “Generalized” epileptic seizures elicited by electrical stimulation of the frontal lobe in man Electroencephalography and Clinical Neurophysiology. ,vol. 37, pp. 275- 282 ,(1974) , 10.1016/0013-4694(74)90031-5
P.C. Emson, O. Lindvall, Distribution of putative neurotransmitters in the neocortex Neuroscience. ,vol. 4, pp. 1- 30 ,(1979) , 10.1016/0306-4522(79)90215-X
M.N. Perkins, T.W. Stone, J.F. Collins, K. Curry, Phosphonate analogues of carboxylic acids as aminoacid antagonists on rat cortical neurones. Neuroscience Letters. ,vol. 23, pp. 333- 336 ,(1981) , 10.1016/0304-3940(81)90021-5
Brian Ault, Michael Gruenthal, David R. Armstrong, J. Victor Nadler, Ching M. Wang, Baclofen suppresses bursting activity induced in hippocampal slices by differing convulsant treatments. European Journal of Pharmacology. ,vol. 126, pp. 289- 292 ,(1986) , 10.1016/0014-2999(86)90059-2
Marco A.C. Benedito, J.R. Leite, Baclofen as an anticonvulsant in experimental models of convulsions. Experimental Neurology. ,vol. 72, pp. 346- 351 ,(1981) , 10.1016/0014-4886(81)90228-4
Granger G.C. Hwa, Massimo Avoli, NMDA receptor antagonists CPP and MK-801 partially suppress the epileptiform discharges induced by the convulsant drug bicuculline in the rat neocortex. Neuroscience Letters. ,vol. 98, pp. 189- 193 ,(1989) , 10.1016/0304-3940(89)90508-9
G. A. R. JOHNSTON, M. H. HAILSTONE, C. G. FREEMAN, Baclofen: stereoselective inhibition of excitant amino acid release. Journal of Pharmacy and Pharmacology. ,vol. 32, pp. 230- 231 ,(2011) , 10.1111/J.2042-7158.1980.TB12902.X
Lechoslaw Turski, Brian S. Meldrum, Waldemar A. Turski, Jeffrey C. Watkins, Evidence that antagonism at non-NMDA receptors results in anticonvulsant action. European Journal of Pharmacology. ,vol. 136, pp. 69- 73 ,(1987) , 10.1016/0014-2999(87)90780-1