An Information-Theoretic Measure for Patterning in Epithelial Tissues

摘要: We present path entropy , an information-theoretic measure that captures the notion of patterning due to phase separation in organic tissues. Recent work has demonstrated, both silico and vitro epithelia can arise simply from forces at play between cells with differing mechanical properties. These qualitative results give rise numerous questions about how degree relates model parameters or underlying biophysical Answering these requires a consistent meaningful way quantifying we observe. define resolution-independent is better suited than image-processing techniques for comparing cellular structures. show this be usefully applied selection scenarios biological experiment computer simulation, argue establishment tissue-graph library assist parameter estimation synthetic morphology.