Transdermal Drug Delivery Systems and their Potential in Alzheimer's Disease Management.

摘要: Alzheimer's disease is a neuropathological with symptoms such as language problems, confusion to place or time, loss of interest in activities, which were previously enjoyed, behavioral changes, and memory loss. other types dementia affect almost 46.8 million people globally are estimated strike about 131.5 2050. It has been reported that the sixth main cause mortality. The most used drugs, currently approved by Food, Drug Administration for donepezil, rivastigmine, galantamine, memantine, combination donepezil memantine. However, drugs present various adverse effects. Recently, transdermal drug delivery route gained increasing attention an emerging tool management. Besides, systems seem provide hope management diseases, due advantages they offer comparison oral dosage forms. Herein, current advancements studies potent features achieve better presented. Many researchers have shown higher efficiency since first-pass hepatic metabolism effect can be avoided prolonged release rate achieved. In summary, administration interesting promising topic, should further elaborated studied.