De novo design of helical peptides to inhibit tumor necrosis factor-α by disrupting its trimer formation
作者： Qi Shen , Changsheng Zhang , Hongbo Liu , Yuting Liu , Junyue Cao
DOI: 10.1039/C5MD00549C
关键词:
摘要: A computational strategy was used to design helical peptides that can bind tumor necrosis factor-α (TNFα) dimers prevent active trimer formation. Three designed showed TNFα inhibition at the cellular level. Chemical crosslinking and mass spectrometry studies verified these function by breaking trimers.
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