Efficacy of Propolis on the Denture Stomatitis Treatment in Older Adults: A Multicentric Randomized Trial
作者： Gisela de MS Pina , Erica N Lia , Andresa A Berretta , Andresa P Nascimento , Elina C Torres
DOI: 10.1155/2017/8971746
关键词:
摘要: Our hypothesis tested the efficacy and safety of a mucoadhesive oral gel formulation Brazilian propolis extract compared to miconazole for treatment denture stomatitis due Candida spp. infection in older adults. Forty patients were randomly allocated noninferiority clinical trial into two groups. The control group (MIC) received 20 mg/g study (PROP) containing standardized 2% (20 mg/g) (EPP-AF®) during 14 days. Patients examined on days 1, 7, 14. Newton’s score was used classify severity stomatitis. colony forming unity count (CFU/mL) quantified identified (CHROMagar Candida®) before after treatment. Baseline characteristics did not differ between Both treatments reduced ( ), indicating improvement symptoms candidiasis with cure rate 70%. microbiological significant reduction fungal burden T14 70% 25% EPP-AF group. appears be noninferior considering could recommended as an alternative patients.
hindawi.com
fapesp.br
core.ac.uk 参考文章(57)
Vincent JC Lempers, Lisa C Martial, Michiel F Schreuder, Nicole M Blijlevens, David M Burger, Rob E Aarnoutse, Roger JM Brüggemann, Drug-interactions of azole antifungals with selected immunosuppressants in transplant patients: strategies for optimal management in clinical practice Current Opinion in Pharmacology. ,vol. 24, pp. 38- 44 ,(2015) , 10.1016/J.COPH.2015.07.002
Renata Longhini, Sheila M. Raksa, Ana Carla P. Oliveira, Terezinha I. E. Svidzinski, Selma L. Franco, Obtenção de extratos de própolis sob diferentes condições e avaliação de sua atividade antifúngica Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy. ,vol. 17, pp. 388- 395 ,(2007) , 10.1590/S0102-695X2007000300015
Sylvana Maria Onofre Duarte, André Ulisses Dantas Batista, Alexandre Henrique de Moura Dias, José Moreira da Silva Neto, Carmem Dolores de Sá Catão, Irma Neuma Coutinho Ramos, Eficiência de substâncias químicas na remoção do biofilme em próteses totais Revista de Odontologia da UNESP. ,vol. 36, pp. 53- 60 ,(2007)
C.M.F. Reis, J.C.T. Carvalho, L.R.G. Caputo, K.C.M. Patricio, M.V.J. Barbosa, A.L. Chieff, J. K. Bastos, Atividade antiinflamatória, antiúlcera gástrica e toxicidade subcrônica do extrato etanólico de própolis Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy. pp. 43- 52 ,(2000) , 10.1590/S0102-695X2000000100005
M. Golecka-Bakowska, E. Mierzwinska-Nastalska, M. Bychawska, Influence of hormone supplementation therapy on the incidence of denture stomatitis and on chemiluminescent activity of polymorphonuclear granulocytes in blood of menopausal-aged women European Journal of Medical Research. ,vol. 15, pp. 46- 49 ,(2010) , 10.1186/2047-783X-15-S2-46
Vincent Bissell, David H. Felix, David Wray, Comparative trial of fluconazole and amphotericin in the treatment of denture stomatitis. Oral Surgery, Oral Medicine, Oral Pathology. ,vol. 76, pp. 35- 39 ,(1993) , 10.1016/0030-4220(93)90290-K
Andresa Aparecida Berretta, Patrícia Alves de Castro, Amanda Henriques Cavalheiro, Vanessa Silveira Fortes, Vinícius Pedro Bom, Andresa Piacezzi Nascimento, Franciane Marquele-Oliveira, Vinícius Pedrazzi, Leandra Naira Zambelli Ramalho, Gustavo Henrique Goldman, None, Evaluation of Mucoadhesive Gels with Propolis (EPP-AF) in Preclinical Treatment of Candidiasis Vulvovaginal Infection Evidence-based Complementary and Alternative Medicine. ,vol. 2013, pp. 641480- 641480 ,(2013) , 10.1155/2013/641480
Danielle Prado Leite, Marta Rabello Piva, Paulo Ricardo Saquete Martins-Filho, Identificação das espécies de Candida em portadores de estomatite protética e avaliação da susceptibilidade ao miconazol e à terapia fotodinâmica Revista de Odontologia da UNESP. ,vol. 44, pp. 12- 17 ,(2015) , 10.1590/1807-2577.1027
Hanadi Lamfon, Stephen R Porter, Michael McCullough, Jonathan Pratten, Susceptibility of Candida albicans biofilms grown in a constant depth film fermentor to chlorhexidine, fluconazole and miconazole: a longitudinal study Journal of Antimicrobial Chemotherapy. ,vol. 53, pp. 383- 385 ,(2004) , 10.1093/JAC/DKH071
EJVIND BUDTZ-JöRGENSEN, The significance of Candida albicans in denture stomatitis European Journal of Oral Sciences. ,vol. 82, pp. 151- 190 ,(1974) , 10.1111/J.1600-0722.1974.TB00378.X