Regulation of translation by the 3' untranslated region of barley yellow dwarf virus-PAV RNA
作者： Shanping Wang
DOI: 10.31274/RTD-180813-10462
关键词:
摘要: Eukaryotic translation initiation is an important step for gene expression. This process stimulated by the interaction of 5' cap and 3' poly (A) tail mediated trans-^c\mg factors. Positive sense viral RNA can differ from cellular mRNA lacking either a cap, or poly(A) both. Therefore, various strategies have evolved viruses to achieve efficient translation. Barley yellow dwarf virus-PAV serotype (BYDVPAV) lacks both tail. I found that sequence (called 3'TE enhancer) at 3'UTR barley genome stimulates uncapped in presence 5'UTR genomic wheat germ extract oat protoplasts. The function be also supported subgenomic RNAl. A four base duplication (GAUC) region abolished stimulatory effect 3'TE. There no difference stability between mRNAs bearing wildtype those defective Capping with without restored its translatability. Moreover, eliminated virus infection. In trans, inhibit containing capped any BYDV-PAV sequences. rra/w-inhibition reversed addition exogenous eIF-4F (eukaryotic factor 4F). importance TE stimulate illustrated fact antisense Judged tiie inhibitory on mRNA, it end virion not capped. mimics RNA2 tiranslation inhibition trans. rroTW-inhibits more significantiy than tiiey model during
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