Expression of the human ferritin light chain in a frataxin mutant yeast affects ageing and cell death.

摘要: Ferritin is one of the major eukaryotic proteins involved in regulating iron metabolism and maintaining homeostasis. However, Saccaromyces cerevisiae an exception, possessing no ferritin using other means to store excess iron. The only potential storage protein identified yeast so far homologue human frataxin (YFH1p). In this study, we found that dysfunction shortens mean lifespan by 49% compared WT control. Interestingly, L gene can, at least partially, complement function frataxin, extending protecting cells from death induced oxidative stress or Our findings indicate can perform functions are similar its mammals, suggest common mechanisms may exist for preventing damage single- multi-cellular organisms. Clearly, elucidation would help gaining a better understanding molecular basis diseases.