Comparison of Spinal Anesthetic Effect between Emulsified Isoflurane and Emulsified Nonimmobilizer F6

摘要: Background: Our previous study found that emulsified isoflurane (EI) produced subarachnoid anesthesia in dogs. The spinal effect of might account for its immobility action. 1, 2-dichlorohexafluorocyclobutane (F6) is a nonimmobilizer incapable causing immobility, it therefore interesting to know whether there are different anesthetic actions between F6 and their underlying mechanisms.Methods: EI were intrathecally injected into rats, motor sensory functions evaluated. Sodium channel currents recorded from neurons. on sodium was examined.Results: (median effective concentration [EC50]at 3.65%). Duration 8% similar 1% lidocaine. Emulsified did not produce at 2% (5 folds predicted EC50). Meanwhile, inhibited with median inhibitory (IC50) 0.81±0.09 mmol/L hyperpolarized voltage-dependent inactivation (from -57.5±2.4 -66.3±1.8 mV, P<0.01). slightly no the gating.Conclusions: Neither action nor observed F6, while neurons channels clinically relevant concentrations anesthesia.  Citation: Jiao Guo, Cheng Zhou, Peng Liang, Xiao-jia Wang, Yi Zhao, Jin Liu. Comparison F6. J Anesth Perioper Med 2015; 2: 1-7. doi: 10.24015/JAPM.2015.0001This an open-access article, published by Evidence Based Communications (EBC). This work licensed under Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, reproduction any medium or format lawful purpose. To view copy this license, visit http://creativecommons.org/licenses/by/4.0/.