Neuroprotective actions of androgens on motoneurons.

摘要: Androgens have a variety of protective and therapeutic effects in both the central peripheral nervous systems. Here we review these as they related specifically to spinal cranial motoneurons. Early development, androgens are critical for formation important neuromuscular sex differences, decreasing magnitude normally occurring cell death select motoneuron populations. Throughout lifespan, also protect against caused by axonal injury. Surviving motoneurons display regressive changes their neurites result direct injury loss neighboring Androgen treatment enhances ability recover from regenerate axons dendrites, restoring normal function. exert acting through molecular pathways. Recent work has begun examine how androgen can interact with other strategies promoting recovery