Antibody formation in mouse bone marrow. I. Evidence for the development of plaque-forming cells in situ.

摘要: Mouse bone marrow as a source of plaque-forming cells (PFC) was studied by single and multiple intravenous injections sheep erythrocytes (SRBC). In the primary response great number PFC appeared in spleen while only few showed up marrow. secondary there is clear PFC-response both The contains majority until about 9 days after second injection. course reaction, however, rises to level which surpasses spleen. IgM-PFC well IgG-PFC IgA-PFC could be demonstrated lymph nodes Peyer's patches did not increase above normal background at any time or immunization. order test whether caused migration from development situ, mice were splenectomized shortly before injection SRBC. It shown that splenectomy does prevent PFC-response. Because no activity other lymphoid organs observed, it concluded situ.