In vitro comparison of the hemocompatibility of two centrifugal left ventricular assist devices

摘要: Abstract Objectives Shear stress from left ventricular assist devices induces von Willebrand factor degradation and platelet dysfunction, leading to nonsurgical bleeding. We characterized the hemostatic changes induced by 2 centrifugal devices, HeartMate 3 (Abbott Inc, Chicago, Ill) EVAHEART (Evaheart Houston, Tex), for comparison. Methods Whole blood 8 healthy volunteers was used ex vivo. Blood same donor 6 hours of circulation in a miniature mock-loop system consisting identical extracorporeal circuits compare following experimental settings: (1) optimal revolutions per minute (rpm) (n = 4; 5000 rpm) 2500 rpm) (2) equal rpm (3000 rpm EVAHEART, n = 4 vs n = 4). For both settings, flow adjusted 1 filling volume (HeartMate 3 = 82 mL/min, EVAHEART = 100 mL/min). A panel coagulation markers analyzed investigate changes. Results The free plasma hemoglobin concentration significantly lower compared with after under settings (optimal: 37 ± 31 503 ± 173 mg/dL, P  Conclusions device caused less hemolysis, resulted activation, provided better preservation functional activity device. These findings prove that design plays major role minimizing damage during support.