Nanoparticulation of BCG-CWS for application to bladder cancer therapy.
作者： Takashi Nakamura , Masafumi Fukiage , Megumi Higuchi , Akihiro Nakaya , Ikuya Yano
DOI: 10.1016/J.JCONREL.2013.12.027
关键词:
摘要: The Mycobacterium bovis Bacille Calmette-Guerin cell wall skeleton (BCG-CWS) could be used to replace live BCG as a bladder cancer drug. However, because BCG-CWS is poorly soluble, has strong-negative charge, very high molecular weight and heterogeneity in size of tens μm, it cannot such an application. We report herein on the development novel packaging method that permits encapsulated into 166nm-sized lipid particles. nano particle (CWS-NP) uniformity can easily dispersed. Thus, potential for use would advance scope applications In functional evaluation, CWS-NP was efficiently taken up by mouse tumor (MBT-2) cells vitro inhibited growth mice bearing MBT-2 tumors. Moreover, intravesically administered showed significant antitumor effects rat model with naturally developed cancer. An enhancement Th1 differentiation also confirmed human T cells. conclusion, represents promising delivery system clinical potent
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