National Cancer Database Analysis of Proton Versus Photon Radiation Therapy in Non-Small Cell Lung Cancer
作者： Kristin A. Higgins , Kelli O'Connell , Yuan Liu , Theresa W. Gillespie , Mark W. McDonald
DOI: 10.1016/J.IJROBP.2016.10.001
关键词:
摘要: Purpose To analyze outcomes and predictors associated with proton radiation therapy for non-small cell lung cancer (NSCLC) in the National Cancer Database. Methods Materials The Database was queried to capture patients stage I-IV NSCLC treated thoracic from 2004 2012. A logistic regression model used determine utilization of therapy. univariate multivariable association overall survival were assessed by Cox proportional hazards models along log–rank tests. propensity score matching method implemented balance baseline covariates eliminate selection bias. Results total 243,822 (photon therapy: 243,474; 348) included analysis. Patients a ZIP code median income P =.011). On multivariate analysis all patients, non-proton significantly worse compared (hazard ratio 1.21 [95% CI 1.06-1.39]; =.025). For II III 1.35 1.10-1.64], Conclusions Thoracic protons is better this retrospective analysis; further validation randomized setting needed account any imbalances patient characteristics, including positron emission tomography–computed tomography staging.
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