Dietary proteins and amino acids in the control of the muscle mass during immobilization and aging: role of the MPS response.

摘要: Dietary proteins/essential amino acids (EAAs) are nutrients with anabolic properties that may increase muscle mass or attenuate loss during immobilization and aging via the stimulation of protein synthesis (MPS). An EAA's threshold, capable to maximize MPS has been hypothesized, but certain conditions associated loss, this threshold seems which reduces efficacy dietary EAAs stimulate MPS. Preliminary studies have demonstrated acute ingestion proteins/EAA (with a sufficient amount leucine) was restore postprandial bed rest, aging; however, whether these improvements translate into chronic increases (or attenuates loss) is equivocal. For example, although free leucine supplementation acutely in some studies, other reported no following supplementation. In contrast, chronically increasing intake consumption an overall appears be most effective intervention toward attenuating lean more research investigating optimal dose timing necessary. Several decreases as result increased circulating oxidative inflammatory responsible than breakdown for disuse health aging. Therefore, nutritional interventions reduce oxidation inflammation conjunction higher intakes overcome resistance enhance response feeding either loss. preliminary antioxidant vitamins anti-inflammatory show potential ingestion. More research, required investigate if and, ultimately, humans. The purpose present review discuss role protein/EAA bring new perspectives challenges aimed optimize effects protein/EAAs