Tumor necrosis factor-alpha and fever after peripheral inflammation in the rat.

摘要: The involvement of endogenous tumor necrosis factor-alpha (TNF-alpha) in the pyrogenic [i.e., rise colonic temperature (Tc)] and thermogenic [increase oxygen consumption (VO2)] responses to inflammation was investigated rats subjected an intramuscular injection turpentine. Turpentine administration caused a Tc VO2 within 2 h (0.9 +/- 0.1 degrees C, 27 2%, respectively). Eighteen twenty hours after turpentine, magnitude these had increased (2.3 C fever 28% increase metabolic rate compared with control animals) associated marked injected limb. A rapid (by 4 h) sustained plasma concentration pyrogen IL-6, but not TNF-alpha, also observed. Intravenous pretreatment TNF-alpha antiserum attenuated observed 2, 8, 18 turpentine almost abolished hypermetabolic response at h. In addition, inhibited peak (8 IL-6 by 76%. These findings indicate that is involved hypermetabolism during it may exert effects inducing release into circulation.