Analysis of Plasma Albumin, Vitamin D, and Apolipoproteins A and B as Predictive Coronary Risk Biomarkers in the REGICOR Study.

摘要: Abstract Introduction and objectives New biomarkers could improve the predictive capacity of classic risk functions. The aims this study were to determine association between circulating levels apolipoprotein A1 (apoA1), B (apoB), albumin, 25-OH-vitamin D coronary events analyze whether these Framingham-REGICOR function. Methods A case-cohort was designed. From an initial cohort 5404 individuals aged 35 74 years with a 5-year follow-up, all participants who had event (n = 117) random group (subcohort; n 667) selected. Finally, 105 cases 651 representative available biological sample included. interest angina, fatal nonfatal myocardial infarction deaths. Results Case older, higher proportion men cardiovascular factors, showed apoB lower apoA1, apoA1/apoB ratio, albumin than subcohort. In multivariate analyses, plasma concentration only biomarker independently associated (HR, 0.73; P .002). inclusion in function properly reclassified significant individuals, especially intermediate (net reclassification improvement, 32.3; .048). Conclusions Plasma are inversely