Pharmacogenomics of antidepressant treatment effects.

摘要: There has been considerable promise and hope that pharmacogenomics will optimize existing treatments for major depression, as well identify novel targets drug discovery. Immediately after the sequencing of human genome, there was much tremendous progress in would rapidly be achieved. In past 10 years this initial enthusiasm replaced by a more sober optimism, we have gone long way towards goal guiding therapeutics based on genomics. While effort to translate discovery clinical applications is ongoing, now vast body knowledge clear direction forward. This article provide critical appraisal state art both terms pharmacodynamics pharmacokinetics.