Inhibition of the acyl-CoA desaturases involved in the biosynthesis of Spodoptera littoralis sex pheromone by analogs of 10,11-methylene-10-tetradecenoic acid
作者： Sergio Rodríguez , Francisco Camps , Gemma Fabriàs
DOI: 10.1016/J.IBMB.2003.11.003
关键词:
摘要: Abstract The desaturase inhibitory activity of the cyclopropenyl alcohols 9,10-methylene-9-tetradecen-1-ol (9-MTOL), 10,11-methylene-10-tetradecen-1-ol (10-MTOL) and 11,12-methylene-11-tetradecen-1-ol (11-MTOL), which are structural analogs 10,11-methylene-10-tetradecenoic acid (10-MTA), is reported. At equimolar ratios with respect to different substrates, three compounds completely inhibited desaturation reactions involved in biosynthesis Spodoptera littoralis sex pheromone. dose-dependence inhibition was determined for 10-MTA its alcohol derivative. Both transformation perdeuterated palmitic into (Z)-11-hexadecenoic that (E)-11-tridecenoic (Z,E)-9,11-tridecadienoic similar IC50 values. overall results presented this work support scattered data neither free carboxyl groups nor their acyl-CoA esters a requisite desaturases. Since synthesis cyclopropenols much more convenient than cyclopropene fatty acids, finding economical relevance regarding putative use derivatives pest control.
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