Photosensitized protein damage by dimethoxyphosphorus(V) tetraphenylporphyrin.
作者： Kazutaka Hirakawa , Norihito Fukunaga , Yoshinobu Nishimura , Tatsuo Arai , Shigetoshi Okazaki
DOI: 10.1016/J.BMCL.2013.02.081
关键词:
摘要: For the purpose of basic study photodynamic therapy, activity water-soluble P(V)porphyrin, dimethoxyP(V)tetraphenylporphyrin chloride (DMP(V)TPP), on photosensitized protein damage was examined. The quantum yield singlet oxygen generation by DMP(V)TPP (0.64) comparable with that typical porphyrin photosensitizers. Absorption spectrum measurement demonstrated binding interaction between and human serum albumin, a protein. Photo-irradiated damaged amino acid residue resulting in decrease fluorescence intensity from tryptophan albumin. A quencher, sodium azide, could not completely inhibit suggesting electron transfer mechanism contributes to as does generation. lifetime albumin supported mechanism. estimated contribution is 0.64. These results suggest can be preserved under lower concentration condition such tumor.
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