Anti-tuberculosis activity and drug interaction with nevirapine of inhalable lipid microspheres containing rifampicin in murine model
作者： Areeya Disratthakit , Norio Doi , Mitsuko Takenaga , Yuki Ohta
DOI: 10.3109/02652040903226507
关键词:
摘要: Intranasal administration of lipid microspheres (LM) containing rifampicin (LM-RFP) exhibited the bacteriostatic effect against Mycobacterium tuberculosis H37Rv. The efficacies intranasal LM-RFP in lung were markedly higher immunodeficient BALB/c nude mice (p < 0.001), but not different immunocompetent = 1.000) compared to results oral groups. When was given instead rifampicin, reductions Cmax and AUC0–3 nevirapine decreased from 32.2% 11.9% 30.5% 12.4%, respectively. These suggested that could improve anti-tuberculosis activity host minimize drug interaction between nevirapine.
sci-hub.se 参考文章(26)
Virginia G Williams, Robert J. Pratt, John M. Grange, Tuberculosis: A Foundation for Nursing and Healthcare Practice ,(2005)
Jieyan Shen, Ben He, Binyao Wang, None, Effects of lipo-prostaglandin E1 on pulmonary hemodynamics and clinical outcomes in patients with pulmonary arterial hypertension. Chest. ,vol. 128, pp. 714- 719 ,(2005) , 10.1016/S0012-3692(15)50417-0
R E Chaisson, H C Clermont, E A Holt, M Cantave, M P Johnson, J Atkinson, H Davis, R Boulos, T C Quinn, N A Halsey, Six-month supervised intermittent tuberculosis therapy in Haitian patients with and without HIV infection. American Journal of Respiratory and Critical Care Medicine. ,vol. 154, pp. 1034- 1038 ,(1996) , 10.1164/AJRCCM.154.4.8887603
L Chapuis, B Ji, C Truffot-Pernot, R J O'Brien, M C Raviglione, J H Grosset, Preventive therapy of tuberculosis with rifapentine in immunocompetent and nude mice. American Journal of Respiratory and Critical Care Medicine. ,vol. 150, pp. 1355- 1362 ,(1994) , 10.1164/AJRCCM.150.5.7952564
Esteban Ribera, Leonor Pou, Rosa M Lopez, Manuel Crespo, Vicenç Falco, Imma Ocaña, Isabel Ruiz, Albert Pahissa, Pharmacokinetic interaction between nevirapine and rifampicin in HIV-infected patients with tuberculosis. Journal of Acquired Immune Deficiency Syndromes. ,vol. 28, pp. 450- 453 ,(2001) , 10.1097/00042560-200112150-00007
SR Penzak, G Kabuye, P Mugyenyi, F Mbamanya, V Natarajan, RM Alfaro, C Kityo, E Formentini, H Masur, Cytochrome P450 2B6 (CYP2B6) G516T influences nevirapine plasma concentrations in HIV-infected patients in Uganda. Hiv Medicine. ,vol. 8, pp. 86- 91 ,(2007) , 10.1111/J.1468-1293.2007.00432.X
K F Law, J Jagirdar, M D Weiden, M Bodkin, W N Rom, Tuberculosis in HIV-positive patients: cellular response and immune activation in the lung. American Journal of Respiratory and Critical Care Medicine. ,vol. 153, pp. 1377- 1384 ,(1996) , 10.1164/AJRCCM.153.4.8616569
Timothy M. Willson, Steven A. Kliewer, Pxr, car and drug metabolism Nature Reviews Drug Discovery. ,vol. 1, pp. 259- 266 ,(2002) , 10.1038/NRD753
Geetha Ramachandran, Agibothu K. Hemanthkumar, Sigamani Rajasekaran, Chandrasekaran Padmapriyadarsini, Gopalan Narendran, Baluswamy Sukumar, Srinivasan Sathishnarayan, Krishnaraj Raja, Vasanthapuram Kumaraswami, Soumya Swaminathan, Increasing nevirapine dose can overcome reduced bioavailability due to rifampicin coadministration. Journal of Acquired Immune Deficiency Syndromes. ,vol. 42, pp. 36- 41 ,(2006) , 10.1097/01.QAI.0000214808.75594.73
M Strolin Benedetti, P Dostert, Induction and autoinduction properties of rifamycin derivatives: a review of animal and human studies. Environmental Health Perspectives. ,vol. 102, pp. 101- 105 ,(1994) , 10.1289/EHP.94102S9101