Polystyrene spheres-assisted matrix-assisted laser desorption ionization mass spectrometry for quantitative analysis of plasma lysophosphatidylcholines.
作者： Yanbo Wei , Shumu Li , Jingxia Wang , Chunying Shu , Jian’an Liu
DOI: 10.1021/AC400452K
关键词:
摘要: The quantitative analysis by matrix-assisted laser desorption ionization mass spectrometry (MALDI MS) is a challenge due to the poor reproducibility originating from heterogeneity of matrix-analyte crystals. Polystyrene (PS) colloidal spheres have superior monodispersed property and can self-assemble form photonic With assistance PS spheres, uniform cocrystal was constructed for plasma lysophosphatidylcholines (LPCs). matrix solvent in MALDI MS were optimized, accuracy investigated detail. This first report about very simple method spheres-assisted analysis, where it believed that this approach will greatly expand applications MS.
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