Overview of major classes of plant-derived anticancer drugs.

摘要: Cancer is the second leading cause of death worldwide. Conventional cancer therapies serious side effects and, at best, merely extend patient’s lifespan by a few years. control may therefore benefit from potential that resides in alternative therapies. The demand to utilize concepts or approaches treatment escalating. There compelling evidence epidemiological and experimental studies highlight importance compounds derived plants “phytochemicals” reduce risk colon inhibit development spread tumors animals. More than 25% drugs used during last 20 years are directly plants, while other chemically altered natural products. Still, only 5-15% approximately 250,000 higher have ever been investigated for bioactive compounds. advantage using such their relatively non-toxic nature availability an ingestive form. An ideal phytochemical one possesses anti-tumor properties with minimal toxicity has defined mechanism action. As target specific signaling pathways identified, researchers can envisage novel therapeutic as well better understanding involved disease progression. Here, we focus on 4 classes anticancer drugs: methyltransferase inhibitors, DNA damaging/pro-oxidant drugs, HDAC inhibitors (HDACi), mitotic disrupters, will mode action promising example per group.