Kinetic resolution of 2,3-epoxy 3-aryl ketones via catalytic asymmetric ring-opening with pyrazole derivatives
作者： Tianyu Huang , Lili Lin , Xiaolei Hu , Jianfeng Zheng , Xiaohua Liu
DOI: 10.1039/C5CC02179K
关键词:
摘要: A highly efficient catalytic kinetic resolution of 2,3-epoxy 3-aryl ketones via asymmetric ring-opening with pyrazole derivatives has been achieved by using a chiral N,N′-dioxide–Sc(III) complex as the catalyst. wide variety substrates were readily scoped, and selectivity factors obtained excellent (up to >300).
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