Nanoshell-Enabled Photothermal Cancer Therapy: Impending Clinical Impact

摘要: Much of the current excitement surrounding nanoscience is directly connected to promise new nanoscale applications in cancer diagnostics and therapy. Because their strongly resonant light-absorbing light-scattering properties that depend on shape, noble metal nanoparticles provide a powerful tool for innovative light-based approaches. Nanoshells—spherical, dielectric core, gold shell nanoparticles—have been central development photothermal therapy past several years. By manipulating nanoparticle researchers can tune optical resonance nanoshells any wavelength interest. At wavelengths just beyond visible spectrum near-infrared, blood tissue are maximally transmissive. When nanoshell resonances tuned this region spectrum, they become useful contrast agents diagnostic imaging tumors. illuminated, serve as heat sources, photothermally inducing cell death tumor r...