Sleep apnea and markers of vascular endothelial function in a large community sample of older adults

摘要: Clinical studies have suggested that sleep apnea is associated with impaired brachial artery flow-mediated dilation, a surrogate of endothelial dysfunction. We examined this question among older participants in the baseline examination Sleep Heart Health/Cardiovascular Health Study cohort (n = 1,037, age 68 years or older, 56% female). Indices apnea, derived from 12-channel home polysomnography, were apnea–hypopnea index (average number apneas/hypopneas per hour) and hypoxemia (percentage time below 90% O2 saturation). Baseline arterial diameter percentage dilation measured by ultrasound. measures although these associations weakened after adjustment for other cardiovascular risk factors, particularly body mass index. However, statistically significant linear association between was observed even afte...