Expression of oestrogen receptor beta (ER beta) occurs in multiple cell types, including some germ cells, in the rat testis

摘要: The identification of a second oestrogen receptor (beta) has prompted re-evaluation the potential sites action oestrogens. aim present study was to characterize immunoexpression ER beta expression in testis complement earlier data which had demonstrated that alpha is confined testicular interstitial Leydig cells. In all testes studied, including those from both fetal (day 20.5 p.c.) and adult rats, found be expressed multiple cell types. Sertoli nuclei were immunopositive at ages. cells not stage dependent unaffected by ablation also peritubular cells, gonocytes. pubertal detected spermatogonia most pachytene spermatocytes. Weak staining cytoplasm spermatocytes undergoing meiotic division. conclusion widespread consistent with role for oestrogens modulating spermatogenesis, hence fertility, male.