Cytokines in the Treatment of Cancer
作者： Kim Margolin , Mark Lazarus , Howard L. Kaufman
DOI: 10.1007/978-1-4614-4732-0_7
关键词:
摘要: Cytokines are molecular mediators of intercellular signaling that function to regulate homeostasis the immune system. There five families cytokines classified by their receptor usage. The effects individual on immunity depend several factors, including local cytokine concentration, pattern expression, and integration multiple pathways in responding cells. have shown therapeutic potential for initiation potentiation antitumor immunity. Interferon-α interleukin-2 (IL-2) been approved as single agents treatment metastatic melanoma renal cell carcinoma, other promise preclinical tumor models. New strategies improving benefit development include cytokine-antibody fusion molecules, delivery recombinant viral vectors, expression irradiated whole cells, PEGylation, DNA vaccination, ex vivo exposure effector
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