Effects of Stirring and Fluid Perfusion on the In Vitro Degradation of Calcium Phosphate Cement/PLGA Composites

摘要: In vitro degradation rates of calcium phosphate bioceramics are investigated using a large variation soaking protocols that do not all match the dynamic conditions perfused physiological environment. Therefore, we studied effect stirring and fluid perfusion on in rate apatitic cements (CPC) containing poly(lactic-co-glycolic acid) (PLGA) microspheres. The composites were soaked phosphate-buffered saline up to 6 weeks under unstirred, stirred, or followed by analysis mass loss, compression strength, porosity, crystal phase composition, morphology cement composites. results showed reduced decrease pH corresponding rates, while nonperfused (i.e., stirred unstirred conditions) resulted into more extensive acidification, which increased with stirring. After 2 weeks, formation secondary brushite was observed for unstirred) conditions, whereas this detected conditions. decreased order unstirred>stirred>perfused, as evidenced quantification pore morphology. To summarize, have demonstrated strongly affected process CPCs. As consequence, it can be concluded experimental design current studies does allow correlation (pre-)clinical studies.