Opipramol, a potent sigma ligand, is an anti-ischemic agent: neurochemical evidence for an interaction with the N-methyl-D-aspartate receptor complex in vivo by cerebellar cGMP measurements.
作者： T RAO , J CLER , S MICK , D RAGAN , T LANTHORN
DOI: 10.1016/0028-3908(90)90045-S
关键词:
摘要: Opipramol, a potent sigma ligand and tricyclic antidepressant compound, provided significant neuronal protection (P < 0.0001) against ischemia-induced cell loss in the hippocampus Mongolian gerbils, at dose of 50 mg/kg (30 min pretreatment). However, opipramol did not oner when given 60 after ischemic insult. Opipramol decreased basal levels cGMP cerebellum mouse harmaline-induced increases cGMP, with approximate ED50 values 4 27 mg/kg. antagonized methamphetamine- pentylenetetrazol-induced cGMP. Parenteral administration also local D-serine, an agonist (NMDA)-associated, strychnine-insensitive glycine receptor. These results indicate that attenuates responses mediated through NMDA receptor complex. further support functional modulation complex by ligands provide neurochemical correlate for observed anti-ischemic properties opipramol.
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